Briefs

Scientists hope method will find patterns in variations of HIV

Wednesday, February 23, 2005 -- By TOM PAULSON
SEATTLE POST-INTELLIGENCER REPORTER

Software scientists at Microsoft Research have teamed up with biomedical researchers in Seattle, Boston and Perth, Australia, to see if computer techniques used to defeat e-mail spam can also be used to help design a vaccine that can defeat AIDS.

Today, members of this unique collaboration will announce a plan to use "machine learning" or "data mining" computational techniques to decipher HIV's wildly creative genetic ability to constantly change and disguise itself from immune system detection and deletion.

"HIV mutates like crazy, but it does show a pattern," said Dr. David Heckerman, a physician and computer scientist at Microsoft Research.

"It isn't completely random," added Heckerman's colleague Nebojsa Jojic. Just as a spammer can add only so much nonsense or other disguising characters without obscuring the message, Jojic said, so can the AIDS virus vary only so much without disabling itself.

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